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Rifabutin Is Inactivated by Mycobacterium abscessus Arr.
Schäfle, Daniel; Selchow, Petra; Borer, Barbara; Meuli, Michael; Rominski, Anna; Schulthess, Bettina; Sander, Peter.
Afiliação
  • Schäfle D; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Selchow P; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Borer B; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Meuli M; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Rominski A; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Schulthess B; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
  • Sander P; National Center for Mycobacteria, University of Zurich, Zurich, Switzerland.
Antimicrob Agents Chemother ; 65(3)2021 02 17.
Article em En | MEDLINE | ID: mdl-33318008
ABSTRACT
Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessusΔarr revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium abscessus / Infecções por Mycobacterium não Tuberculosas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça