Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation.
Epigenomics
; 13(3): 203-218, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33406918
ABSTRACT
Background:
Gestational hyperglycemia is associated with adverse perinatal outcomes and long-term offspring metabolic programming, likely through dysregulation of DNA methylation (DNAm). Materials &methods:
We tested associations between maternal HbA1c and cord blood DNAm among 412 mother-child pairs in the genetics of glucose regulation in gestation and growth (Gen3G) and implemented Mendelian randomization to infer causality. We sought replication in an independent sample from Healthy Start.Results:
Higher second trimester HbA1c levels were associated with lower DNAm at cg21645848 (p = 3.9 × 10-11) near URGCP. Mendelian randomization and replication analyses showed same direction of effect between HbA1c and DNAm at cg21645848, but did not reach statistical significance.Conclusion:
We found that higher maternal glycemia reflected by HbA1c is associated with cord blood DNAm at URGCP, a gene related with inflammatory pathways.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Hemoglobinas Glicadas
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Metilação de DNA
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Sangue Fetal
/
Epigenoma
/
Hiperglicemia
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos