Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1&#945; regulator.

Isomura, Hisanori; Taguchi, Ayumu; Kajino, Taisuke; Asai, Naoya; Nakatochi, Masahiro; Kato, Seiichi; Suzuki, Keiko; Yanagisawa, Kiyoshi; Suzuki, Motoshi; Fujishita, Teruaki; Yamaguchi, Tomoya; Takahashi, Masahide; Takahashi, Takashi

Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.

Isomura, Hisanori; Taguchi, Ayumu; Kajino, Taisuke; Asai, Naoya; Nakatochi, Masahiro; Kato, Seiichi; Suzuki, Keiko; Yanagisawa, Kiyoshi; Suzuki, Motoshi; Fujishita, Teruaki; Yamaguchi, Tomoya; Takahashi, Masahide; Takahashi, Takashi.

Afiliação

Isomura H; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Taguchi A; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Kajino T; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Asai N; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nakatochi M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kato S; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Suzuki K; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yanagisawa K; Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
Suzuki M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Fujishita T; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
Yamaguchi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahashi M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahashi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Cancer Sci ; 112(4): 1614-1623, 2021 Apr.

Article em En | MEDLINE | ID: mdl-33506575

Assuntos

Adenocarcinoma de Pulmão/genética; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Neoplasias Pulmonares/genética; Receptores Órfãos Semelhantes a Receptor Tirosina Quinase/genética; Adenocarcinoma de Pulmão/patologia; Animais; Linhagem Celular Tumoral; Regulação para Baixo/genética; Regulação Neoplásica da Expressão Gênica/genética; Humanos; Hipóxia/genética; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Oncogenes/genética; Transdução de Sinais/genética; Fator Nuclear 1 de Tireoide/genética; Microambiente Tumoral/genética

Palavras-chave

EGFR; HIF-1α; ROR1; genetically engineered mouse model; lung adenocarcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidade alfa do Fator 1 Induzível por Hipóxia / Receptores Órfãos Semelhantes a Receptor Tirosina Quinase / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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