IRGM1 links mitochondrial quality control to autoimmunity.

Rai, Prashant; Janardhan, Kyathanahalli S; Meacham, Julie; Madenspacher, Jennifer H; Lin, Wan-Chi; Karmaus, Peer W F; Martinez, Jennifer; Li, Quan-Zhen; Yan, Mei; Zeng, Jialiu; Grinstaff, Mark W; Shirihai, Orian S; Taylor, Gregory A; Fessler, Michael B

Rai, Prashant; Janardhan, Kyathanahalli S; Meacham, Julie; Madenspacher, Jennifer H; Lin, Wan-Chi; Karmaus, Peer W F; Martinez, Jennifer; Li, Quan-Zhen; Yan, Mei; Zeng, Jialiu; Grinstaff, Mark W; Shirihai, Orian S; Taylor, Gregory A; Fessler, Michael B.

Afiliação

Rai P; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. prashant.rai@nih.gov.
Janardhan KS; Cellular & Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Meacham J; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA.
Madenspacher JH; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Lin WC; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Karmaus PWF; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Martinez J; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Li QZ; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Yan M; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Zeng J; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Grinstaff MW; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shirihai OS; Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Taylor GA; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Fessler MB; Department of Biomedical Engineering, Boston University, Boston, MA, USA.

Nat Immunol ; 22(3): 312-321, 2021 03.

Article em En | MEDLINE | ID: mdl-33510463

Assuntos

Doenças Autoimunes/metabolismo; Autoimunidade; Fibroblastos/metabolismo; Proteínas de Ligação ao GTP/metabolismo; Mitocôndrias/metabolismo; Mitofagia; Animais; Doenças Autoimunes/genética; Doenças Autoimunes/imunologia; Doenças Autoimunes/patologia; Células Cultivadas; Fibroblastos/imunologia; Fibroblastos/patologia; Proteínas de Ligação ao GTP/deficiência; Proteínas de Ligação ao GTP/genética; Regulação da Expressão Gênica; Macrófagos/imunologia; Macrófagos/metabolismo; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos Endogâmicos C57BL; Mitocôndrias/genética; Mitocôndrias/imunologia; Mitocôndrias/patologia; Nucleotidiltransferases/genética; Nucleotidiltransferases/metabolismo; Transdução de Sinais; Receptor 7 Toll-Like/genética; Receptor 7 Toll-Like/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Autoimunidade / Proteínas de Ligação ao GTP / Fibroblastos / Mitofagia / Mitocôndrias Limite: Animals Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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