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Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions.
Deng, Liting; Gupta, Vivek K; Wu, Yunqi; Pushpitha, Kanishka; Chitranshi, Nitin; Gupta, Veer B; Fitzhenry, Matthew J; Moghaddam, Masoud Zabet; Karl, Tim; Salekdeh, Ghasem Hosseini; Graham, Stuart L; Haynes, Paul A; Mirzaei, Mehdi.
Afiliação
  • Deng L; Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, Australia.
  • Gupta VK; Faculty of Medicine and Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Wu Y; Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, Australia.
  • Pushpitha K; Faculty of Medicine and Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Chitranshi N; Faculty of Medicine and Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Gupta VB; School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Fitzhenry MJ; Australian Proteome Analysis Facility (APAF), Macquarie University, Sydney, New South Wales, Australia.
  • Moghaddam MZ; Center for Biotechnology and Genomics, Texas Tech University, Lubbock, Texas, USA.
  • Karl T; School of Medicine, Western Sydney University, Penrith, New South Wales, Australia.
  • Salekdeh GH; Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, Australia.
  • Graham SL; Faculty of Medicine and Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Haynes PA; Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, Australia.
  • Mirzaei M; Faculty of Medicine and Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Proteomics ; 21(7-8): e2000213, 2021 04.
Article em En | MEDLINE | ID: mdl-33559908
ABSTRACT
Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Proteoma / Doença de Alzheimer Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Proteoma / Doença de Alzheimer Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália