Glycans in Immunologic Health and Disease.
Annu Rev Immunol
; 39: 511-536, 2021 04 26.
Article
em En
| MEDLINE
| ID: mdl-33577348
ABSTRACT
The surfaces of all living organisms and most secreted proteins share a common feature They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Interações Hospedeiro-Patógeno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2021
Tipo de documento:
Article