ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis.

To, Jeffrey C; Chiu, Amy P; Tschida, Barbara R; Lo, Lilian H; Chiu, Cynthia H; Li, Xiao-Xiao; Kuka, Timothy P; Linden, Michael A; Amin, Khalid; Chan, Wing-Cheung; Bell, Jason B; Moriarity, Branden S; Largaespada, David A; Keng, Vincent W

To, Jeffrey C; Chiu, Amy P; Tschida, Barbara R; Lo, Lilian H; Chiu, Cynthia H; Li, Xiao-Xiao; Kuka, Timothy P; Linden, Michael A; Amin, Khalid; Chan, Wing-Cheung; Bell, Jason B; Moriarity, Branden S; Largaespada, David A; Keng, Vincent W.

Afiliação

To JC; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Chiu AP; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Tschida BR; Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Lo LH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Chiu CH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Li XX; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Kuka TP; Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Linden MA; College of Natural Sciences, The University of Texas at Austin, Austin, TX, 78712, USA.
Amin K; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Chan WC; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Bell JB; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Moriarity BS; Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Largaespada DA; Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.
Keng VW; Masonic Cancer Center, Department of Pediatrics, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, 55455, USA.

JHEP Rep ; 3(2): 100223, 2021 Apr.

Article em En | MEDLINE | ID: mdl-33604532

Palavras-chave

AFP, alpha-foetoprotein; BTB/POZ, broad complex; CTNNB1; CTNNB1, catenin beta 1; Fah, fumarylacetoacetate hydrolase; GSK3B, glycogen synthase kinase 3 beta; HCC, hepatocellular carcinoma; HHL, immortalized human hepatic cell line; Hepatocellular carcinoma; IF, immunofluorescence; NTBC, 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; OFP, orange fluorescent protein; PHI, post-hydrodynamic injection; POK, POZ and Kruppel; PPARG; PPARG, peroxisome proliferator activated receptor gamma; Reverse genetic screen; SB, Sleeping Beauty; Sleeping Beauty; ZBTB20; ZBTB20, zinc finger and BTB domain containing 20; qPCR, quantitative RT-PCR; tramtrack, bric a brac/poxvirus and zinc finger

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2021 Tipo de documento: Article