T cell responses to Chlamydia.
Pathog Dis
; 79(4)2021 03 31.
Article
em En
| MEDLINE
| ID: mdl-33693620
ABSTRACT
Chlamydia trachomatis is the most commonly reported sexually transmitted infection in the United States. The high prevalence of infection and lack of a vaccine indicate a critical knowledge gap surrounding the host's response to infection and how to effectively generate protective immunity. The immune response to C. trachomatis is complex, with cells of the adaptive immune system playing a crucial role in bacterial clearance. Here, we discuss the CD4+ and CD8+ T cell response to Chlamydia, the importance of antigen specificity and the role of memory T cells during the recall response. Ultimately, a deeper understanding of protective immune responses is necessary to develop a vaccine that prevents the inflammatory diseases associated with Chlamydia infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Infecções por Chlamydia
/
Chlamydia trachomatis
/
Linfócitos T CD8-Positivos
/
Evasão da Resposta Imune
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pathog Dis
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos