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Effects of chloroquine or hydroxychloroquine treatment on non-SARS-CoV2 viral infections: A systematic review of clinical studies.
Cui, Xizhong; Sun, Junfeng; Minkove, Samuel J; Li, Yan; Cooper, Diane; Couse, Zoe; Eichacker, Peter Q; Torabi-Parizi, Parizad.
Afiliação
  • Cui X; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Sun J; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Minkove SJ; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Li Y; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Cooper D; NIH Library, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
  • Couse Z; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Eichacker PQ; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
  • Torabi-Parizi P; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, USA.
Rev Med Virol ; 31(6): e2228, 2021 11.
Article em En | MEDLINE | ID: mdl-33694220
Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used as antiviral agents for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. We performed a systematic review to examine whether prior clinical studies that compared the effects of CQ and HCQ to a control for the treatment of non-SARS-CoV2 infection supported the use of these agents in the present SARS-CoV2 outbreak. PubMed, EMBASE, Scopus and Web of Science (PROSPERO CRD42020183429) were searched from inception through 2 April 2020 without language restrictions. Of 1766 retrieved reports, 18 studies met our inclusion criteria, including 17 prospective controlled studies and one retrospective study. CQ or HCQ were compared to control for the treatment of infectious mononucleosis (EBV, n = 4), warts (human papillomavirus, n = 2), chronic HIV infection (n = 6), acute chikungunya infection (n = 1), acute dengue virus infection (n = 2), chronic HCV (n = 2), and as preventive measures for influenza infection (n = 1). Survival was not evaluated in any study. For HIV, the virus that was most investigated, while two early studies suggested HCQ reduced viral levels, four subsequent ones did not, and in two of these CQ or HCQ increased viral levels and reduced CD4 counts. Overall, three studies concluded CQ or HCQ were effective; four concluded further research was needed to assess the treatments' effectiveness; and 11 concluded that treatment was ineffective or potentially harmful. Prior controlled clinical trials with CQ and HCQ for non-SARS-CoV2 viral infections do not support these agents' use for the SARS-CoV2 outbreak.
Assuntos
Febre de Chikungunya/tratamento farmacológico; Cloroquina/uso terapêutico; Infecções por HIV/tratamento farmacológico; Hepatite C Crônica/tratamento farmacológico; Hidroxicloroquina/uso terapêutico; Mononucleose Infecciosa/tratamento farmacológico; Dengue Grave/tratamento farmacológico; Verrugas/tratamento farmacológico; Alphapapillomavirus/efeitos dos fármacos; Alphapapillomavirus/imunologia; Alphapapillomavirus/patogenicidade; Antivirais/uso terapêutico; COVID-19/virologia; Febre de Chikungunya/imunologia; Febre de Chikungunya/patologia; Febre de Chikungunya/virologia; Vírus Chikungunya/efeitos dos fármacos; Vírus Chikungunya/imunologia; Vírus Chikungunya/patogenicidade; Vírus da Dengue/efeitos dos fármacos; Vírus da Dengue/imunologia; Vírus da Dengue/patogenicidade; HIV/efeitos dos fármacos; HIV/imunologia; HIV/patogenicidade; Infecções por HIV/imunologia; Infecções por HIV/patologia; Infecções por HIV/virologia; Hepacivirus/efeitos dos fármacos; Hepacivirus/imunologia; Hepacivirus/patogenicidade; Hepatite C Crônica/imunologia; Hepatite C Crônica/patologia; Hepatite C Crônica/virologia; Herpesvirus Humano 4/efeitos dos fármacos; Herpesvirus Humano 4/imunologia; Herpesvirus Humano 4/patogenicidade; Humanos; Mononucleose Infecciosa/imunologia; Mononucleose Infecciosa/patologia; Mononucleose Infecciosa/virologia; SARS-CoV-2/imunologia; SARS-CoV-2/patogenicidade; Dengue Grave/imunologia; Dengue Grave/patologia; Dengue Grave/virologia; Resultado do Tratamento; Verrugas/imunologia; Verrugas/patologia; Verrugas/virologia; Tratamento Farmacológico da COVID-19
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Verrugas / Infecções por HIV / Cloroquina / Dengue Grave / Hepatite C Crônica / Febre de Chikungunya / Hidroxicloroquina / Mononucleose Infecciosa Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Rev Med Virol Assunto da revista: VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Verrugas / Infecções por HIV / Cloroquina / Dengue Grave / Hepatite C Crônica / Febre de Chikungunya / Hidroxicloroquina / Mononucleose Infecciosa Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Rev Med Virol Assunto da revista: VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos