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Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity.
Nagi, Karim; Habib, Abdella M.
Afiliação
  • Nagi K; College of Medicine, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar. Electronic address: knagi@qu.edu.qa.
  • Habib AM; College of Medicine, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar. Electronic address: ahabib@qu.edu.qa.
Cell Signal ; 83: 109976, 2021 07.
Article em En | MEDLINE | ID: mdl-33713808
Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of the hypothalamus to regulate feeding behavior and glucose homeostasis through its G protein-coupled receptor. Recently, several central pathways modulating the metabolic actions of ghrelin have been reported. While these signaling pathways can be inhibited or activated by antagonists or agonists, they can also be discriminatingly activated in a "biased" response to impart different degrees of activation in distinct pathways downstream of the receptor. Here, we review recent ghrelin biased signaling findings as well as characteristics of ghrelin hormone and its receptors pertinent for biased signaling. We then evaluate the feasibility for ghrelin receptor biased signaling as a strategy for the development of effective pharmacotherapy in obesity treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Grelina / Receptores de Grelina / Comportamento Alimentar / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Signal Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Grelina / Receptores de Grelina / Comportamento Alimentar / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Signal Ano de publicação: 2021 Tipo de documento: Article