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Five-Year Adjuvant Endocrine Therapy Adherence Trajectories Among Women With Breast Cancer: A Nationwide French Study Using Administrative Data.
Lailler, Grégory; Memoli, Victoria; Le Bihan Benjamin, Christine; Ben Diane, Marc-Karim; Lauzier, Sophie; Mancini, Julien; Bousquet, Philippe Jean; Bouhnik, Anne-Déborah.
Afiliação
  • Lailler G; Health data and assessment department; Survey, data-science and assessment division, Institut National du Cancer (INCa), Boulogne Billancourt, France. Electronic address: glailler@hotmail.fr.
  • Memoli V; Aix Marseille Univ, Inserm, IRD, SESSTIM, Equipe Labellisée Ligue Contre le Cancer, Marseille, France.
  • Le Bihan Benjamin C; Health data and assessment department; Survey, data-science and assessment division, Institut National du Cancer (INCa), Boulogne Billancourt, France.
  • Ben Diane MK; Aix Marseille Univ, Inserm, IRD, SESSTIM, Equipe Labellisée Ligue Contre le Cancer, Marseille, France.
  • Lauzier S; Faculty of Pharmacy, Université Laval, Québec City, Québec, Canada; CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Axis Équipe de Recherche Michel-Sarrazin en Oncologie Psychosociale et Soins Palliatifs (ERMOS), Québec City, Quebec, Canada; Centre des
  • Mancini J; Aix Marseille Univ, Inserm, IRD, SESSTIM, Equipe Labellisée Ligue Contre le Cancer, Marseille, France; APHM, Hop Timone, BioSTIC, Marseille, France.
  • Bousquet PJ; Aix Marseille Univ, Inserm, IRD, SESSTIM, Equipe Labellisée Ligue Contre le Cancer, Marseille, France; Survey, data-science and assessment division, Institut National du Cancer (INCa), Boulogne Billancourt, France.
  • Bouhnik AD; Aix Marseille Univ, Inserm, IRD, SESSTIM, Equipe Labellisée Ligue Contre le Cancer, Marseille, France.
Clin Breast Cancer ; 21(4): e415-e426, 2021 08.
Article em En | MEDLINE | ID: mdl-33745868
BACKGROUND: Adjuvant endocrine therapy (AET) improves long-term survival of breast cancer patients, yet many women are nonadherent or discontinue this treatment. In this study we aimed to describe AET adherence trajectories over 5 years after treatment initiation and to identify factors associated with these trajectories, in a nationwide French cohort of breast cancer survivors. PATIENTS AND METHODS: Every woman diagnosed with a first nonmetastatic breast cancer in 2011 in France who initiated AET in the 12 months after surgery was included from the French cancer cohort. We identified all reimbursements for AET from national health administrative data sets and modeled AET adherence trajectories over 5 years, using group-based trajectory modeling on the basis of the monthly proportion of days covered by AET. Associated factors were identified using multinomial logistic regressions. RESULTS: We included 33,260 women. A 6-trajectory model was selected: 1, immediate discontinuation (6.6%); 2, continuous suboptimal adherence (4.3%); 3, progressive nonadherence then discontinuation (6.3%); 4, early nonadherence then discontinuation (5.7%); 5, continuous optimal adherence (68.8%); and 6, late nonadherence then discontinuation (8.3%). The main factors associated with nonadherence trajectories were extreme age (younger than 50 and older than 70 years) and switching AET. CONCLUSION: Approximately 70% of women had optimal adherence over all 5 years. The original nationwide approach enabled us to identify the "continuous suboptimal adherence trajectory" never previously described.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Antineoplásicos Hormonais / Antagonistas de Estrogênios / Adesão à Medicação / Sobreviventes de Câncer Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Breast Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Antineoplásicos Hormonais / Antagonistas de Estrogênios / Adesão à Medicação / Sobreviventes de Câncer Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Breast Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article