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Repair of DNA Breaks by Break-Induced Replication.
Kockler, Z W; Osia, B; Lee, R; Musmaker, K; Malkova, A.
Afiliação
  • Kockler ZW; Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu.
  • Osia B; Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu.
  • Lee R; Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu.
  • Musmaker K; Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu.
  • Malkova A; Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu.
Annu Rev Biochem ; 90: 165-191, 2021 06 20.
Article em En | MEDLINE | ID: mdl-33792375
Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One such pathway is break-induced replication (BIR), which repairs primarily one-ended DSBs, similar to those formed by collapsed replication forks or telomere erosion. BIR is initiated by the invasion of a broken DNA end into a homologous template, synthesizes new DNA within the context of a migrating bubble, and is associated with conservative inheritance of new genetic material. This mode of synthesis is responsible for a high level of genetic instability associated with BIR. Eukaryotic BIR was initially investigated in yeast, but now it is also actively studied in mammalian systems. Additionally, a significant breakthrough has been made regarding the role of microhomology-mediated BIR in the formation of complex genomic rearrangements that underly various human pathologies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo do DNA / Replicação do DNA / Quebras de DNA de Cadeia Dupla / Homeostase do Telômero / Mamíferos Limite: Animals / Humans Idioma: En Revista: Annu Rev Biochem Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo do DNA / Replicação do DNA / Quebras de DNA de Cadeia Dupla / Homeostase do Telômero / Mamíferos Limite: Animals / Humans Idioma: En Revista: Annu Rev Biochem Ano de publicação: 2021 Tipo de documento: Article