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Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Chiou, Joshua; Zeng, Chun; Cheng, Zhang; Han, Jee Yun; Schlichting, Michael; Miller, Michael; Mendez, Robert; Huang, Serina; Wang, Jinzhao; Sui, Yinghui; Deogaygay, Allison; Okino, Mei-Lin; Qiu, Yunjiang; Sun, Ying; Kudtarkar, Parul; Fang, Rongxin; Preissl, Sebastian; Sander, Maike; Gorkin, David U; Gaulton, Kyle J.
Afiliação
  • Chiou J; Biomedical Graduate Studies Program, University of California, San Diego, La Jolla, CA, USA.
  • Zeng C; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Cheng Z; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Han JY; Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
  • Schlichting M; Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
  • Miller M; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Mendez R; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Huang S; Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
  • Wang J; Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
  • Sui Y; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Deogaygay A; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Okino ML; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Qiu Y; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Sun Y; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Kudtarkar P; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Fang R; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Preissl S; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Sander M; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Gorkin DU; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.
  • Gaulton KJ; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Nat Genet ; 53(4): 455-466, 2021 04.
Article em En | MEDLINE | ID: mdl-33795864
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Células Secretoras de Somatostatina / Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagon / Células Secretoras de Insulina / Células Secretoras de Polipeptídeo Pancreático / Canal de Potássio KCNQ1 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Células Secretoras de Somatostatina / Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagon / Células Secretoras de Insulina / Células Secretoras de Polipeptídeo Pancreático / Canal de Potássio KCNQ1 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos