Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis.

Pizzo, Lucilla; Lasser, Micaela; Yusuff, Tanzeen; Jensen, Matthew; Ingraham, Phoebe; Huber, Emily; Singh, Mayanglambam Dhruba; Monahan, Connor; Iyer, Janani; Desai, Inshya; Karthikeyan, Siddharth; Gould, Dagny J; Yennawar, Sneha; Weiner, Alexis T; Pounraja, Vijay Kumar; Krishnan, Arjun; Rolls, Melissa M; Lowery, Laura Anne; Girirajan, Santhosh

Pizzo, Lucilla; Lasser, Micaela; Yusuff, Tanzeen; Jensen, Matthew; Ingraham, Phoebe; Huber, Emily; Singh, Mayanglambam Dhruba; Monahan, Connor; Iyer, Janani; Desai, Inshya; Karthikeyan, Siddharth; Gould, Dagny J; Yennawar, Sneha; Weiner, Alexis T; Pounraja, Vijay Kumar; Krishnan, Arjun; Rolls, Melissa M; Lowery, Laura Anne; Girirajan, Santhosh.

Afiliação

Pizzo L; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Lasser M; Department of Biology, Boston College, Chestnut Hill, MA, United States of America.
Yusuff T; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Jensen M; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Ingraham P; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Huber E; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Singh MD; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Monahan C; Department of Biology, Boston College, Chestnut Hill, MA, United States of America.
Iyer J; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Desai I; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Karthikeyan S; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Gould DJ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Yennawar S; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Weiner AT; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Pounraja VK; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Krishnan A; Department of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI, United States of America.
Rolls MM; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States of America.
Lowery LA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.
Girirajan S; Department of Medicine, Boston University Medical Center, Boston, MA, United States of America.

PLoS Genet ; 17(4): e1009112, 2021 04.

Article em En | MEDLINE | ID: mdl-33819264

Assuntos

Encéfalo/metabolismo; Deleção Cromossômica; Cromossomos Humanos Par 16/genética; Transtornos do Neurodesenvolvimento/genética; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Encéfalo/patologia; Canais de Cálcio/genética; Moléculas de Adesão Celular/genética; Proteínas de Ligação a DNA/genética; Modelos Animais de Doenças; Proteínas de Drosophila/genética; Drosophila melanogaster/genética; Epistasia Genética/genética; Regulação da Expressão Gênica no Desenvolvimento; Humanos; Metiltransferases/genética; Transtornos do Neurodesenvolvimento/patologia; Proteínas Nucleares/genética; PTEN Fosfo-Hidrolase/genética; Fatores de Transcrição/genética; Ubiquitina-Proteína Ligases/genética; Proteínas de Xenopus/genética; Xenopus laevis/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Par 16 / Encéfalo / Deleção Cromossômica / Transtornos do Neurodesenvolvimento Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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