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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
van Vliet, Thijmen; Varela-Eirin, Marta; Wang, Boshi; Borghesan, Michela; Brandenburg, Simone M; Franzin, Rossana; Evangelou, Konstantinos; Seelen, Marc; Gorgoulis, Vassilis; Demaria, Marco.
Afiliação
  • van Vliet T; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
  • Varela-Eirin M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
  • Wang B; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
  • Borghesan M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
  • Brandenburg SM; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
  • Franzin R; Experimental Nephrology Department, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, the Netherlands.
  • Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece.
  • Seelen M; Experimental Nephrology Department, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, the Netherlands.
  • Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9NQ, UK; Biomedic
  • Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands. Electronic address: m.demaria@umcg.nl.
Mol Cell ; 81(9): 2041-2052.e6, 2021 05 06.
Article em En | MEDLINE | ID: mdl-33823141
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Proliferação de Células / Proteínas Quinases Ativadas por AMP / Serina-Treonina Quinases TOR / Hipóxia Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Proliferação de Células / Proteínas Quinases Ativadas por AMP / Serina-Treonina Quinases TOR / Hipóxia Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda