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An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes.
Ubbiali, Daniele; Orlando, Marco; Kovacic, Matic; Iacobucci, Claudio; Semrau, Marta S; Bajc, Gregor; Fortuna, Sara; Ilc, Gregor; Medagli, Barbara; Oloketuyi, Sandra; Storici, Paola; Sinz, Andrea; Grandori, Rita; de Marco, Ario.
Afiliação
  • Ubbiali D; Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Germany.
  • Orlando M; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100 Varese, Italy.
  • Kovacic M; Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia.
  • Iacobucci C; Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Germany.
  • Semrau MS; Structural Biology Lab, Elettra Sincrotrone Trieste S.C.p.A., 34149, Basovizza, Trieste, Italy; CIBIO, Centre for Integrative Biology, University of Trento, via Sommarive 9, Povo 38123, Italy.
  • Bajc G; Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia.
  • Fortuna S; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.
  • Ilc G; Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia.
  • Medagli B; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.
  • Oloketuyi S; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, 5000 Rozna Dolina, Nova Gorica, Slovenia.
  • Storici P; Structural Biology Lab, Elettra Sincrotrone Trieste S.C.p.A., 34149, Basovizza, Trieste, Italy.
  • Sinz A; Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, Germany.
  • Grandori R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
  • de Marco A; Lab of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, 5000 Rozna Dolina, Nova Gorica, Slovenia. Electronic address: ario.demarco@ung.si.
Int J Biol Macromol ; 182: 502-511, 2021 Jul 01.
Article em En | MEDLINE | ID: mdl-33848543
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sítios de Ligação de Anticorpos / Receptor ErbB-2 / Anticorpos de Cadeia Única Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sítios de Ligação de Anticorpos / Receptor ErbB-2 / Anticorpos de Cadeia Única Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha