Immunophenotypic switch in cutaneous T-cell lymphoma: A series of three cases and review of the literature.
J Cutan Pathol
; 48(7): 986-994, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33856064
ABSTRACT
Primary cutaneous T-cell lymphoma (CTCL) comprises a heterogeneous group of neoplasms with variable clinical behavior. Immunophenotypic switch (IS) is a phenomenon that occurs during lymphoma progression and is defined by an alteration in the immunophenotypic expression of a tumor with retention of its genotypic signature. This has been well-recognized in hematopoietic neoplasms; however, it has been rarely reported in CTCL and its clinical implications are not well understood. We present the clinical, histopathologic, immunophenotypic, and genetic findings of three cases of CTCL that demonstrated IS post treatment with variable outcomes. We add our cases to the small number previously reported to increase awareness of this phenomenon and its diagnostic challenge.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Transformação Celular Neoplásica
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Imunofenotipagem
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Linfoma Cutâneo de Células T
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Micose Fungoide
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos