P53 regulates cellular redox state, ferroptosis and metabolism.

Leu, Julia I-Ju; Murphy, Maureen E; George, Donna L

Leu, Julia I-Ju; Murphy, Maureen E; George, Donna L.

Afiliação

Leu JI; Department of Genetics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Murphy ME; Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
George DL; Department of Genetics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Mol Cell Oncol ; 8(2): 1877076, 2021.

Article em En | MEDLINE | ID: mdl-33860080

ABSTRACT

ABSTRACT

The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.

Palavras-chave

Ferroptosis; cysteine modification; metabolism; p53; redox signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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