Low- vs. high-dose radiotherapy in Graves' ophthalmopathy: a retrospective comparison of long-term results.
Strahlenther Onkol
; 197(10): 885-894, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-33860819
ABSTRACT
PURPOSE:
Radiotherapy represents an effective treatment option in Graves' ophthalmopathy (GO), leading to palliation of clinical symptoms. However, there are only a limited number of trials comparing the effectiveness of low- vs. high-dose radiotherapy.METHODS:
We analyzed 127 patients treated with radiotherapy for stage 3/4 GO (NOSPECS classification). Patients were treated with single doses of 2.0â¯Gy (cumulative dose 20â¯Gy) until 2007, afterwards a single dose of 0.8â¯Gy (cumulative dose 4.8â¯Gy) was applied. With a median follow-up-time of 9.0 years, the treatment efficacy (overall improvement, sense of eye pressure, lid edema, ocular motility, exophthalmos, subjective vision, and diplopia) and adverse effects were analyzed by a standardized survey.RESULTS:
Overall, 63.8% described improvement of symptoms after radiotherapy. No significant differences in overall treatment response and improvement of main outcome measures between low- or high-dose radiotherapy treatments are detectable, while low-dose radiotherapy leads significantly more often to retreatment (13.1% vs. 1.7%, pâ¯= 0.016). The main independent predictor of treatment response is the presence of lid edema (odds ratio, OR, 3.53; pâ¯= 0.006).CONCLUSION:
At long-term follow-up, the majority of patients reported palliation of symptoms with limited adverse effects, suggesting clinical effectiveness of radiotherapy for amelioration of GO symptoms independent of low- or high-dose radiotherapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exoftalmia
/
Oftalmopatia de Graves
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Strahlenther Onkol
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha