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The occurrence order and cross-talk of different tRNA modifications.
Li, Jing; Zhu, Wen-Yu; Yang, Wen-Qing; Li, Cai-Tao; Liu, Ru-Juan.
Afiliação
  • Li J; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Zhu WY; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Yang WQ; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Li CT; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Liu RJ; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. liurj@shanghaitech.edu.cn.
Sci China Life Sci ; 64(9): 1423-1436, 2021 Sep.
Article em En | MEDLINE | ID: mdl-33881742
Chemical modifications expand the composition of RNA molecules from four standard nucleosides to over 160 modified nucleosides, which greatly increase the complexity and utility of RNAs. Transfer RNAs (tRNAs) are the most heavily modified cellular RNA molecules and contain the largest variety of modifications. Modification of tRNAs is pivotal for protein synthesis and also precisely regulates the noncanonical functions of tRNAs. Defects in tRNA modifications lead to numerous human diseases. Up to now, more than 100 types of modifications have been found in tRNAs. Intriguingly, some modifications occur widely on all tRNAs, while others only occur on a subgroup of tRNAs or even only a specific tRNA. The modification frequency of each tRNA is approximately 7% to 25%, with 5-20 modification sites present on each tRNA. The occurrence and modulation of tRNA modifications are specifically noticeable as plenty of interplays among different sites and modifications have been discovered. In particular, tRNA modifications are responsive to environmental changes, indicating their dynamic and highly organized nature. In this review, we summarized the known occurrence order, cross-talk, and cooperativity of tRNA modifications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / RNA de Transferência / Fenômenos Fisiológicos Celulares / Processamento Pós-Transcricional do RNA Limite: Humans Idioma: En Revista: Sci China Life Sci Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / RNA de Transferência / Fenômenos Fisiológicos Celulares / Processamento Pós-Transcricional do RNA Limite: Humans Idioma: En Revista: Sci China Life Sci Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China