Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons.
J Neurophysiol
; 125(5): 2000-2012, 2021 05 01.
Article
em En
| MEDLINE
| ID: mdl-33881911
ABSTRACT
This study demonstrates that the action potential discharge in vagal afferent A-fiber neurons is about 20 times more sensitive to the rate of membrane depolarization compared to C-fiber neurons. The sensitivity of action potential generation to the depolarization rate in vagal sensory neurons is independent of the intensity of current stimuli but nearly abrogated by inhibiting the D-type potassium channel. These findings help better understand the mechanisms that control the activation of vagal afferent nerves.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Fibras Nervosas Amielínicas
/
Superfamília Shaker de Canais de Potássio
/
Fibras Nervosas Mielinizadas
/
Neurônios Aferentes
/
Gânglio Nodoso
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos