Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease.

Shen, Cong-Rong; Jia, Xiao-Yu; Luo, Wentian; Olaru, Florina; Cui, Zhao; Zhao, Ming-Hui; Borza, Dorin-Bogdan

Shen, Cong-Rong; Jia, Xiao-Yu; Luo, Wentian; Olaru, Florina; Cui, Zhao; Zhao, Ming-Hui; Borza, Dorin-Bogdan.

Afiliação

Shen CR; Renal Division, Institute of Nephrology, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Jia XY; Renal Division, Institute of Nephrology, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Luo W; Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
Olaru F; Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.
Cui Z; Renal Division, Institute of Nephrology, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Zhao MH; Renal Division, Institute of Nephrology, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Borza DB; Peking-Tsinghua Center for Life Sciences, Beijing, China.

J Am Soc Nephrol ; 32(8): 1887-1897, 2021 08.

Article em En | MEDLINE | ID: mdl-33893224

Assuntos

Doença Antimembrana Basal Glomerular/sangue; Autoanticorpos/sangue; Hemoptise/sangue; Imunoglobulina G/sangue; Laminina/imunologia; Adulto; Idoso; Animais; Doença Antimembrana Basal Glomerular/complicações; Autoantígenos/imunologia; Estudos de Casos e Controles; Colágeno Tipo IV/imunologia; Colágeno Tipo IV/metabolismo; Creatinina/sangue; Progressão da Doença; Epitopos/imunologia; Feminino; Hemoptise/complicações; Humanos; Rim/metabolismo; Falência Renal Crônica/etiologia; Pulmão/metabolismo; Masculino; Camundongos; Pessoa de Meia-Idade; Prognóstico; Proteinúria/etiologia; Estudos Retrospectivos; Saimiri; Fumar/sangue

Palavras-chave

Goodpasture's syndrome; anti-GBM disease; autoantibodies; extracellular matrix; glomerular basement membrane; glomerulonephritis; laminin; pulmonary hemorrhage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Imunoglobulina G / Laminina / Doença Antimembrana Basal Glomerular / Hemoptise Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Soc Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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