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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
Karabegovic, Irma; Portilla-Fernandez, Eliana; Li, Yang; Ma, Jiantao; Maas, Silvana C E; Sun, Daokun; Hu, Emily A; Kühnel, Brigitte; Zhang, Yan; Ambatipudi, Srikant; Fiorito, Giovanni; Huang, Jian; Castillo-Fernandez, Juan E; Wiggins, Kerri L; de Klein, Niek; Grioni, Sara; Swenson, Brenton R; Polidoro, Silvia; Treur, Jorien L; Cuenin, Cyrille; Tsai, Pei-Chien; Costeira, Ricardo; Chajes, Veronique; Braun, Kim; Verweij, Niek; Kretschmer, Anja; Franke, Lude; van Meurs, Joyce B J; Uitterlinden, André G; de Knegt, Robert J; Ikram, M Arfan; Dehghan, Abbas; Peters, Annette; Schöttker, Ben; Gharib, Sina A; Sotoodehnia, Nona; Bell, Jordana T; Elliott, Paul; Vineis, Paolo; Relton, Caroline; Herceg, Zdenko; Brenner, Hermann; Waldenberger, Melanie; Rebholz, Casey M; Voortman, Trudy; Pan, Qiuwei; Fornage, Myriam; Levy, Daniel; Kayser, Manfred; Ghanbari, Mohsen.
Afiliação
  • Karabegovic I; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Portilla-Fernandez E; Department of Genetic Identification, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Li Y; Epidemiology and Microbial Genomics, National Health Laboratory, Dudelange, Luxembourg.
  • Ma J; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Maas SCE; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Sun D; Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  • Hu EA; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study, Framingham, MA, USA.
  • Kühnel B; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Zhang Y; Department of Genetic Identification, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Ambatipudi S; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Fiorito G; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Huang J; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Castillo-Fernandez JE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Wiggins KL; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • de Klein N; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Grioni S; AMCHSS, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
  • Swenson BR; Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, Cedex 08, France.
  • Polidoro S; Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
  • Treur JL; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
  • Cuenin C; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
  • Tsai PC; UK Dementia Research Institute at Imperial College London, London, UK.
  • Costeira R; Imperial College NIHR Biomedical Research Centre, London, UK.
  • Chajes V; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
  • Braun K; Epigenetics Programme, Babraham Institute, Cambridge, UK.
  • Verweij N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU, Seattle, WA, USA.
  • Kretschmer A; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Franke L; Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation, Milan, Italy.
  • van Meurs JBJ; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU, Seattle, WA, USA.
  • Uitterlinden AG; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
  • de Knegt RJ; Italian Institute for Genomic Medicine (IIGM, former HuGeF), c/o IRCCS Candiolo, Candiolo, Italy.
  • Ikram MA; Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands.
  • Dehghan A; Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, Cedex 08, France.
  • Peters A; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
  • Schöttker B; Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.
  • Gharib SA; Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Sotoodehnia N; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
  • Bell JT; Nutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
  • Elliott P; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Vineis P; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Relton C; Genomics plc, Park End St, Oxford, UK.
  • Herceg Z; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Brenner H; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Waldenberger M; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Rebholz CM; Oncode Institute, Utrecht, The Netherlands.
  • Voortman T; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Pan Q; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Fornage M; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Levy D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Kayser M; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, Norfolk Place, London, UK.
  • Ghanbari M; UK Dementia Research Institute at Imperial College London, London, UK.
Nat Commun ; 12(1): 2830, 2021 05 14.
Article em En | MEDLINE | ID: mdl-33990564
ABSTRACT
Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10-7), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10-6). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chá / Café / Metilação de DNA / Epigenoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chá / Café / Metilação de DNA / Epigenoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda