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Advanced Diagnostic Technology of Volatile Organic Compounds Real Time analysis Analysis From Exhaled Breath of Gastric Cancer Patients Using Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry.
Jung, Yoon Ju; Seo, Ho Seok; Kim, Ji Hyun; Song, Kyo Young; Park, Cho Hyun; Lee, Han Hong.
Afiliação
  • Jung YJ; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Seo HS; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Kim JH; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Song KY; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Park CH; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Lee HH; Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Front Oncol ; 11: 560591, 2021.
Article em En | MEDLINE | ID: mdl-33996531
ABSTRACT

BACKGROUND:

Screening endoscopy is considered to be the most accurate tool for early detection of gastric cancer, but it is both invasive and costly. It is therefore essential to develop cost-effective and non-invasive diagnostic tools for gastric cancer. The aim of this study is to investigate the presence of certain volatile organic compounds (VOCs) associated with gastric cancer and to survey the usefulness of VOCs as screening tools of gastric cancer.

METHODS:

The present study was conducted prospectively to identify the relationship between gastric cancer and specific VOCs quantified by mass spectrometry. Exhaled breath samples from a total of 43 participants were analysed. This study was approved by the Institutional Review Board of the College of Medicine, Catholic University of Korea (KC16TISI0598), and registered to clinical research information service (KCT0004356).

RESULTS:

Nine VOCs differed significantly between the control and cancer patient groups. When participants were divided into control, early gastric cancer (EGC), and advanced gastric cancer (AGC) groups, seven VOCs remained significantly different. Of these, four (propanal, aceticamide, isoprene and 1,3 propanediol) showed gradual increases as cancer advanced, from normal control to EGC to AGC. In receiver operating characteristic curves for these four VOCs, the area under the curve for gastric cancer prediction was highest (0.842) when more than two VOCs were present.

CONCLUSIONS:

The present study offers potential directions for non-invasive gastric cancer screening, and may inspire advanced diagnostic technologies in the era of smart home healthcare. However, despite the high accuracy, cancer-specific VOCs from several studies on different populations, and analytic methods show inconsistency, it is necessary to establish standards for each analytical method, and to validate on each population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul