[Renal actions of bendamustin (Cytostasan) in rats]. / Renale Wirkungen von Bendamustin (Cytostasan) bei Ratten.
Pharmazie
; 43(4): 265-8, 1988 Apr.
Article
em De
| MEDLINE
| ID: mdl-3413216
ABSTRACT
In adult rats influences of single doses of bendamustin (0.5, 1 or 5 mg/100 g b.wt. i.p.) on kidney function were measured (time of experimentation 8 d following administration). Bendamustin administration is followed by an increase of kidney weight caused by a higher water content of kidney tissue. An increase of plasma concentrations of creatinine and of urea following bendamustin (1 or 5 mg/100 g b.wt. i.p.) indicates a reduced excretion capacity of kidney. Bendamustin administration is not connected with a distinct proteinuria. The highest administered does (5 mg bendamustin/100 g b.wt. i.p.) caused an oliguric effect connected with a distinctly reduced renal excretion of osmotically active substances. There is a distinct diminution of renal excretion of sodium following bendamustin administration and a decrease of renal excretion of PAH can be stated. It is most likely that bendamustin can reduce the glomerular function Following administration of 1 mg bendamustin/100 g b. wt. i.p. CIn is reduced whereas a statistically significant increase of tubular transport capacity for organic anions can be measured (TmPAH).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rim
/
Compostos de Mostarda Nitrogenada
Limite:
Animals
Idioma:
De
Revista:
Pharmazie
Assunto da revista:
FARMACIA
Ano de publicação:
1988
Tipo de documento:
Article