Quantitative Analysis of the Dynamics of Maternal Gradients in the Early Drosophila Embryo.
J Comput Biol
; 28(8): 747-757, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34152850
ABSTRACT
Predetermination, formation, and maintenance of the primary morphogenetic gradient (bicoid, bcd) of the early Drosophila embryo involves many interrelated processes. Here we focus on the biological systems analysis of the bcd mRNA redistribution in an early embryo. The results of the quantitative analysis of experimental data, together with the results of their dynamic modeling, substantiate the role of active transport in the redistribution of the bcd mRNA. The role of the nonlinearity of degradation mechanisms in the mRNA pattern robustness is discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transativadores
/
Proteínas de Homeodomínio
/
Proteínas de Drosophila
/
Drosophila
/
Microtúbulos
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Limite:
Animals
Idioma:
En
Revista:
J Comput Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
INFORMATICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Federação Russa