A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice.
JHEP Rep
; 3(4): 100295, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-34159304
CAR-T, chimeric antigen receptor T cells; CFSE, carboxy-fluorescein succinimidyl ester; CHB, chronic hepatitis B; CTL, cytotoxic T lymphocyte; Chronic hepatitis B; DCs, dendritic cells; ELISPOT, enzyme-linked ImmunoSpot; GzmB, granzyme B; HBV; HBc, HBV core antigen; HBp, HBV polymerase antigen; HBs, HBV surface antigen; ICS, intracellular cytokine staining; IFNγ, interferon γ; MHC, major histocompatibility complex; NanoLuc, nanoluciferase; STAT2, signal transducer and activator of transcription 2; TNFα, tumour necrosis factor α; Therapeutic vaccination; YF, yellow fever; Yellow fever vaccine; aa, amino acids; cccDNA, covalently closed circular DNA; ifnar, IFN-α/ß receptor; pfu, plaque-forming units; rHBc, recombinant HBc; t-SNE, t-stochastic neighbour embedding; wt, wild-type
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
JHEP Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Bélgica