Urinary metabolomics analysis of the protective effects of Daming capsule on hyperlipidemia rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.

Zhao, Wenting; An, Ran; Liu, Fangtong; Gu, Jintao; Sun, Yue; Xu, Silun; Pan, Yumiao; Gao, Zhiyuan; Ji, Hongyu; Du, Zhimin

Zhao, Wenting; An, Ran; Liu, Fangtong; Gu, Jintao; Sun, Yue; Xu, Silun; Pan, Yumiao; Gao, Zhiyuan; Ji, Hongyu; Du, Zhimin.

Afiliação

Zhao W; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
An R; Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, P. R. China.
Liu F; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Gu J; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Sun Y; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Xu S; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Pan Y; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Gao Z; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Ji H; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.
Du Z; Institute of Clinical Pharmacy, The Second Affiliated Hospital of Harbin Medical University, The University Key Laboratory of Drug Research, Heilongjiang Higher Education Institutions, Harbin, P. R. China.

J Sep Sci ; 44(17): 3305-3318, 2021 Sep.

Article em En | MEDLINE | ID: mdl-34185383

Assuntos

Medicamentos de Ervas Chinesas/análise; Hiperlipidemias/urina; Hipolipemiantes/análise; Metabolômica; Substâncias Protetoras/análise; Substâncias Protetoras/uso terapêutico; Administração Oral; Animais; Cápsulas/análise; Cápsulas/metabolismo; Cápsulas/uso terapêutico; Cromatografia Líquida de Alta Pressão; Dieta Hiperlipídica/efeitos adversos; Medicamentos de Ervas Chinesas/metabolismo; Medicamentos de Ervas Chinesas/uso terapêutico; Hiperlipidemias/tratamento farmacológico; Hiperlipidemias/metabolismo; Hipolipemiantes/metabolismo; Hipolipemiantes/uso terapêutico; Masculino; Espectrometria de Massas; Substâncias Protetoras/metabolismo; Ratos; Ratos Wistar; Software; Fatores de Tempo

Palavras-chave

Daming capsule; biomarkers; hyperlipidemia; metabolomics; traditional Chinese medicine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Substâncias Protetoras / Metabolômica / Hiperlipidemias / Hipolipemiantes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Sep Sci Ano de publicação: 2021 Tipo de documento: Article

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