A cross-linked anti-TNF-&#945; aptamer for neutralization of TNF-&#945;-induced cutaneous Shwartzman phenomenon: A simple and novel approach for improving aptamers' affinity and efficiency.

Mashayekhi, Kazem; Sankian, Mojtaba; Haftcheshmeh, Saeed Mohammadian; Taheri, Ramezan Ali; Hassanpour, Kazem; Farnoosh, Gholamreza

A cross-linked anti-TNF-α aptamer for neutralization of TNF-α-induced cutaneous Shwartzman phenomenon: A simple and novel approach for improving aptamers' affinity and efficiency.

Mashayekhi, Kazem; Sankian, Mojtaba; Haftcheshmeh, Saeed Mohammadian; Taheri, Ramezan Ali; Hassanpour, Kazem; Farnoosh, Gholamreza.

Afiliação

Mashayekhi K; Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sankian M; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Haftcheshmeh SM; Immuno-Biochemistry lab, Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Taheri RA; Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Hassanpour K; Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Farnoosh G; Medical School, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Biotechnol Prog ; 37(5): e3191, 2021 09.

Article em En | MEDLINE | ID: mdl-34218531

Assuntos

Aptâmeros de Nucleotídeos; Fenômeno de Shwartzman/metabolismo; Inibidores do Fator de Necrose Tumoral; Fator de Necrose Tumoral alfa/metabolismo; Animais; Aptâmeros de Nucleotídeos/química; Aptâmeros de Nucleotídeos/metabolismo; Aptâmeros de Nucleotídeos/farmacologia; Linhagem Celular; Feminino; Camundongos; Camundongos Endogâmicos BALB C; Inibidores do Fator de Necrose Tumoral/química; Inibidores do Fator de Necrose Tumoral/metabolismo; Inibidores do Fator de Necrose Tumoral/farmacologia

Palavras-chave

Shwartzman phenomenon; TNF-α; aptamer; multivalent aptamer; trimethyl aconitate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenômeno de Shwartzman / Fator de Necrose Tumoral alfa / Aptâmeros de Nucleotídeos / Inibidores do Fator de Necrose Tumoral Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotechnol Prog Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Irã

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