Your browser doesn't support javascript.
loading
Ligilactobacillus Salivarius LCK11 Prevents Obesity by Promoting PYY Secretion to Inhibit Appetite and Regulating Gut Microbiota in C57BL/6J Mice.
Liang, Cong; Zhou, Xiao-Hong; Jiao, Yue-Hua; Guo, Mei-Jie; Meng, Li; Gong, Pi-Min; Lyu, Lin-Zheng; Niu, Hai-Yue; Wu, Yi-Fan; Chen, Shi-Wei; Han, Xue; Zhang, Lan-Wei.
Afiliação
  • Liang C; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Zhou XH; Qingdao Central Hospital, Qingdao, 266042, China.
  • Jiao YH; Drug safety evaluation center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.
  • Guo MJ; Department of Adolescent Medical Clinic, Harbin Children's Hospital, Harbin, 150010, China.
  • Meng L; Engineering Research Center of Agricultural Microbiology Technology, Heilongjiang University, Harbin, 150500, China.
  • Gong PM; College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
  • Lyu LZ; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Niu HY; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Wu YF; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Chen SW; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Han X; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150010, China.
  • Zhang LW; College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Mol Nutr Food Res ; 65(17): e2100136, 2021 09.
Article em En | MEDLINE | ID: mdl-34272917
SCOPE: Obesity is a common disease worldwide and there is an urgent need for strategies to preventing obesity. METHODS AND RESULTS: The anti-obesity effect and mechanism of Ligilactobacillus salivarius LCK11 (LCK11) is studied using a C57BL/6J male mouse model in which obesity is induced by a high-fat diet (HFD). Results show that LCK11 can prevent HFD-induced obesity, reflected as inhibited body weight gain, abdominal and liver fat accumulation and dyslipidemia. Analysis of its mechanism shows that on the one hand, LCK11 can inhibit food intake through significantly improving the transcriptional and translational levels of peptide YY (PYY) in the rectum, in addition to the eventual serum PYY level; this is attributed to the activation of the toll-like receptor 2/nuclear factor-κB signaling pathway in enteroendocrine L cells by the peptidoglycan of LCK11. On the other hand, LCK11 supplementation effectively reduces the Firmicutes/Bacteroidetes ratio and shifts the overall structure of the HFD-disrupted gut microbiota toward that of mice fed on a low-fat diet; this also contributes to preventing obesity. CONCLUSION: LCK11 shows the potential to be used as a novel probiotic for preventing obesity by both promoting PYY secretion to inhibit food intake and regulating gut microbiota.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactobacillaceae / Peptídeo YY / Microbioma Gastrointestinal / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Mol Nutr Food Res Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactobacillaceae / Peptídeo YY / Microbioma Gastrointestinal / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Mol Nutr Food Res Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China