CDK4/6 inhibitor-induced colitis: a case report and review of the literature.
BMJ Case Rep
; 14(7)2021 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-34312131
ABSTRACT
A 72-year-old woman with metastatic ER/PR-positive breast cancer who had been on ribociclib and letrozole for 1 year developed severe life-threatening colitis. She presented to emergency department with features of acute abdomen and diarrhoea. The diagnosis of colitis was confirmed radiologically as well as by histopathological examination of the biopsy specimen and the patient clinically improved after withholding ribociclib and receiving corticosteroids compatible with ribociclib-induced colitis. The mechanism of injury in CDK 4/6 inhibitor-induced colitis is unknown but may be related to recruitment of inflammatory cells. Whether the development of colitis is associated with tumour response is an interesting and unanswered question.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Neoplasias da Mama
/
Colite
/
Quinase 4 Dependente de Ciclina
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Quinase 6 Dependente de Ciclina
/
Aminopiridinas
Limite:
Aged
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Female
/
Humans
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido