Bimetallic Metal-Organic Frameworks: Enhanced Peroxidase-like Activities for the Self-Activated Cascade Reaction.
ACS Appl Mater Interfaces
; 13(30): 36106-36116, 2021 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-34313120
ABSTRACT
Metal-organic frameworks (MOFs) are significant useful molecular materials as a result of their high surface area and flexible catalytic activities by tuning the metal centers and ligands. MOFs have attracted great attention as efficient nanozymes recently; however, it is still difficult to understand polymetallic MOFs for enzymatic catalysis because of their complicated structure and interactions. Herein, bimetallic NiFe2 MOF octahedra were well prepared and exhibited enhanced peroxidase-like activities. The synergistic effect of Fe and Ni atoms was systematically investigated by electrochemistry, X-ray photoelectron spectrometry, (XPS) and in situ Raman techniques. The electrons tend to transfer from Ni2+ to Fe3+ in NiFe2 MOFs, and the resulting Fe2+ is ready to decompose H2O2 and generate ·OH by a Fenton-like reaction. After integration with glucose oxidase (GOx), which can downgrade the pH value and generate H2O2 by oxidation of glucose, a self-activated cascade reagent is therefore established for efficiently inducing cell death. The changes of cell morphology, DNA, and protein are also successfully recorded during the cell death process by Raman spectroscopy and fluorescence imaging.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estruturas Metalorgânicas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Assunto da revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Ano de publicação:
2021
Tipo de documento:
Article