Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and miscarriage by upregulating IP<sub>3</sub> R<sub>1</sub> /CaMKII/SGCB pathway by competitively binding with miR-hz04.

Huang, Wenxin; Dai, Mengyuan; Qiu, Taotao; Liang, Tingting; Xie, Jiayu; Mi, Chenyang; Zhao, Jingsong; Chen, Weina; Tian, Peng; Zhang, Shuming; Zhang, Huidong

Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and miscarriage by upregulating IP₃ R₁ /CaMKII/SGCB pathway by competitively binding with miR-hz04.

Huang, Wenxin; Dai, Mengyuan; Qiu, Taotao; Liang, Tingting; Xie, Jiayu; Mi, Chenyang; Zhao, Jingsong; Chen, Weina; Tian, Peng; Zhang, Shuming; Zhang, Huidong.

Afiliação

Huang W; Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Dai M; Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou, China.
Qiu T; Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Liang T; Department of Toxicology, School of Public Health, Fujian Medical University, Fuzhou, China.
Xie J; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Mi C; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Zhao J; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Chen W; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Tian P; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Zhang S; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.
Zhang H; Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China.

FASEB J ; 35(9): e21789, 2021 09.

Article em En | MEDLINE | ID: mdl-34383983

Assuntos

Aborto Habitual/genética; Apoptose/genética; MicroRNAs/genética; RNA Longo não Codificante/genética; Transdução de Sinais/genética; Trofoblastos/metabolismo; Regulação para Cima/genética; 7,8-Di-Hidro-7,8-Di-Hidroxibenzo(a)pireno 9,10-óxido/farmacologia; Aborto Habitual/tratamento farmacológico; Animais; Apoptose/efeitos dos fármacos; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética; Linhagem Celular; Regulação para Baixo/efeitos dos fármacos; Regulação para Baixo/genética; Feminino; Humanos; Receptores de Inositol 1,4,5-Trifosfato/genética; Camundongos; Camundongos Endogâmicos C57BL; Gravidez; Sarcoglicanas/genética; Transdução de Sinais/efeitos dos fármacos; Trofoblastos/efeitos dos fármacos; Regulação para Cima/efeitos dos fármacos

Palavras-chave

IP3R1/Ca2+/CaMKII/SGCB; competing endogenous RNAs (ceRNAs); environmental BaP or BPDE; female trophoblast cell apoptosis; miscarriage or spontaneous abortion; noncoding lncRNA-HZ04 and miR-hz04

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trofoblastos / Transdução de Sinais / Regulação para Cima / Aborto Habitual / Apoptose / MicroRNAs / RNA Longo não Codificante Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google