A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis.

Wang, Tingting; Liu, Zhenchuan; She, Yunlang; Deng, Jiajun; Zhong, Yifan; Zhao, Mengmeng; Li, Shenghui; Xie, Dong; Sun, Xiwen; Hu, Xuefei; Chen, Chang

Wang, Tingting; Liu, Zhenchuan; She, Yunlang; Deng, Jiajun; Zhong, Yifan; Zhao, Mengmeng; Li, Shenghui; Xie, Dong; Sun, Xiwen; Hu, Xuefei; Chen, Chang.

Afiliação

Wang T; Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: growingwtt@163.com.
Liu Z; Department of Thoracic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: liuzhenchuan1991@hotmail.com.
She Y; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: sylxan3344@163.com.
Deng J; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: 1831228@tongji.edu.cn.
Zhong Y; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: yifanzhong@126.com.
Zhao M; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: zhaosurgery@163.com.
Li S; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: 1911523@tongji.edu.cn.
Xie D; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: kongduxd@163.com.
Sun X; Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: sunxiwen5256@163.com.
Hu X; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: huxuefei_12345@163.com.
Chen C; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: changchenc@tongji.edu.cn.

Cancer Lett ; 520: 321-331, 2021 11 01.

Article em En | MEDLINE | ID: mdl-34389432

Assuntos

Adenocarcinoma de Pulmão/tratamento farmacológico; Gefitinibe/farmacologia; MAP Quinase Quinase Quinase 5/genética; RNA Circular/genética; Proteínas de Ligação a RNA/genética; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/patologia; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Gefitinibe/efeitos adversos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Inibidores de Proteínas Quinases/efeitos adversos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ASK1; Akt1; Gefitinib resistance; Lung adenocarcinoma; circRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / MAP Quinase Quinase Quinase 5 / Gefitinibe / Adenocarcinoma de Pulmão / RNA Circular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2021 Tipo de documento: Article

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