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Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation.
Afrin, Sadia; El Sabeh, Malak; Islam, Md Soriful; Miyashita-Ishiwata, Mariko; Malik, Minnie; Catherino, William H; Akimzhanov, Askar M; Boehning, Darren; Yang, Qiwei; Al-Hendy, Ayman; Segars, James H; Borahay, Mostafa A.
Afiliação
  • Afrin S; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • El Sabeh M; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Islam MS; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Miyashita-Ishiwata M; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Malik M; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Catherino WH; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  • Akimzhanov AM; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA.
  • Boehning D; Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, USA.
  • Yang Q; Department of Gynecology and Obstetrics, University of Chicago School of Medicine, Chicago, IL 60637, USA.
  • Al-Hendy A; Department of Gynecology and Obstetrics, University of Chicago School of Medicine, Chicago, IL 60637, USA.
  • Segars JH; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Borahay MA; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: mboraha1@jhmi.edu.
Pharmacol Res ; 172: 105856, 2021 10.
Article em En | MEDLINE | ID: mdl-34461224
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Receptor alfa de Estrogênio / Estrogênios / Leiomioma Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Female / Humans / Middle aged Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Receptor alfa de Estrogênio / Estrogênios / Leiomioma Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Female / Humans / Middle aged Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos