Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-ß upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury.

Nakazaki, Masahito; Morita, Tomonori; Lankford, Karen L; Askenase, Philip W; Kocsis, Jeffery D

Nakazaki, Masahito; Morita, Tomonori; Lankford, Karen L; Askenase, Philip W; Kocsis, Jeffery D.

Afiliação

Nakazaki M; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Morita T; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, USA.
Lankford KL; Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Askenase PW; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Kocsis JD; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

J Extracell Vesicles ; 10(11): e12137, 2021 09.

Article em En | MEDLINE | ID: mdl-34478241

Assuntos

Vesículas Extracelulares/metabolismo; Macrófagos/metabolismo; Células-Tronco Mesenquimais/metabolismo; Traumatismos da Medula Espinal/genética; Fator de Crescimento Transformador beta/metabolismo; Animais; Modelos Animais de Doenças; Masculino; Ratos; Ratos Sprague-Dawley; Regulação para Cima

Palavras-chave

blood-spinal cord barrier; exosomes; macrophages; mesenchymal stem/stromal cells; small extracellular vesicles; spinal cord injury; transforming growth factor-beta

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Fator de Crescimento Transformador beta / Células-Tronco Mesenquimais / Vesículas Extracelulares / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Extracell Vesicles Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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