Somatic intronic TP53 c.375+5G mutations are a recurrent but under-recognized mode of TP53 inactivation.

Chui, M Herman; Yang, Ciyu; Mehta, Nikita; Rai, Vikas; Zehir, Ahmet; Momeni Boroujeni, Amir; Ladanyi, Marc; Mandelker, Diana

Chui, M Herman; Yang, Ciyu; Mehta, Nikita; Rai, Vikas; Zehir, Ahmet; Momeni Boroujeni, Amir; Ladanyi, Marc; Mandelker, Diana.

Afiliação

Chui MH; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yang C; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mehta N; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rai V; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zehir A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Momeni Boroujeni A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ladanyi M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mandelker D; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

J Pathol Clin Res ; 8(1): 14-18, 2022 01.

Article em En | MEDLINE | ID: mdl-34505757

Assuntos

Splicing de RNA; Proteína Supressora de Tumor p53; Humanos; Íntrons/genética; Mutação; Proteína Supressora de Tumor p53/genética

Palavras-chave

TP53; cancer; intronic mutation; p53; pathogenic variant

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Splicing de RNA / Proteína Supressora de Tumor p53 Limite: Humans Idioma: En Revista: J Pathol Clin Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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