Your browser doesn't support javascript.
loading
Stress in paradise: effects of elevated corticosterone on immunity and avian malaria resilience in a Hawaiian passerine.
Names, Gabrielle R; Schultz, Elizabeth M; Krause, Jesse S; Hahn, Thomas P; Wingfield, John C; Heal, Molly; Cornelius, Jamie M; Klasing, Kirk C; Hunt, Kathleen E.
Afiliação
  • Names GR; Animal Behavior Graduate Group, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
  • Schultz EM; Department of Neurobiology, Physiology and Behavior, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
  • Krause JS; Department of Biology, Wittenberg University, 200 W Ward Street, Springfield, OH 45504, USA.
  • Hahn TP; Department of Biology, University of Nevada Reno, 1664 North Virginia Street, Reno, NV 89557, USA.
  • Wingfield JC; Department of Neurobiology, Physiology and Behavior, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
  • Heal M; Department of Neurobiology, Physiology and Behavior, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
  • Cornelius JM; Department of Neurobiology, Physiology and Behavior, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
  • Klasing KC; Department of Integrative Biology, Oregon State University, 2701 SW Campus Way, Corvallis, OR 97331, USA.
  • Hunt KE; Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
J Exp Biol ; 224(20)2021 10 15.
Article em En | MEDLINE | ID: mdl-34553762
Vertebrates confronted with challenging environments often experience an increase in circulating glucocorticoids, which result in morphological, physiological and behavioral changes that promote survival. However, chronically elevated glucocorticoids can suppress immunity, which may increase susceptibility to disease. Since the introduction of avian malaria to Hawaii a century ago, low-elevation populations of Hawaii Amakihi (Chlorodrepanis virens) have undergone strong selection by avian malaria and evolved increased resilience (the ability to recover from infection), while populations at high elevation with few vectors have not undergone selection and remain susceptible. We investigated how experimentally elevated corticosterone affects the ability of high- and low-elevation male Amakihi to cope with avian malaria by measuring innate immunity, hematocrit and malaria parasitemia. Corticosterone implants resulted in a decrease in hematocrit in high- and low-elevation birds but no changes to circulating natural antibodies or leukocytes. Overall, leukocyte count was higher in low- than in high-elevation birds. Malaria infections were detected in a subset of low-elevation birds. Infected individuals with corticosterone implants experienced a significant increase in circulating malaria parasites while untreated infected birds did not. Our results suggest that Amakihi innate immunity measured by natural antibodies and leukocytes is not sensitive to changes in corticosterone, and that high circulating corticosterone may reduce the ability of Amakihi to cope with infection via its effects on hematocrit and malaria parasite load. Understanding how glucocorticoids influence a host's ability to cope with introduced diseases provides new insight into the conservation of animals threatened by novel pathogens.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium / Passeriformes / Malária Aviária Limite: Animals / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Exp Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium / Passeriformes / Malária Aviária Limite: Animals / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Exp Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos