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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Paes Dias, Mariana; Tripathi, Vivek; van der Heijden, Ingrid; Cong, Ke; Manolika, Eleni-Maria; Bhin, Jinhyuk; Gogola, Ewa; Galanos, Panagiotis; Annunziato, Stefano; Lieftink, Cor; Andújar-Sánchez, Miguel; Chakrabarty, Sanjiban; Smith, Graeme C M; van de Ven, Marieke; Beijersbergen, Roderick L; Bartkova, Jirina; Rottenberg, Sven; Cantor, Sharon; Bartek, Jiri; Ray Chaudhuri, Arnab; Jonkers, Jos.
Afiliação
  • Paes Dias M; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands.
  • Tripathi V; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
  • van der Heijden I; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands.
  • Cong K; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Manolika EM; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands.
  • Bhin J; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Robotics and Screening Center, Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands.
  • Gogola E; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands.
  • Galanos P; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen 2100, Denmark.
  • Annunziato S; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands.
  • Lieftink C; Robotics and Screening Center, Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Andújar-Sánchez M; Pathology Department, Complejo Hospitalario Universitario Insular, Las Palmas, Gran Canaria, Spain.
  • Chakrabarty S; Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Karnataka 576104, India.
  • Smith GCM; Artios Pharma, Glenn Berge Building, Babraham Research Campus, Cambridge CB22 3FH, UK.
  • van de Ven M; Mouse Clinic for Cancer and Aging, Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Beijersbergen RL; Robotics and Screening Center, Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Bartkova J; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Science for Life Laboratory, Stockholm 171 77, Sweden.
  • Rottenberg S; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern 3012, Switzerland.
  • Cantor S; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Bartek J; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Science for Life Laboratory, Stockholm 171 77, Sweden.
  • Ray Chaudhuri A; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands. Electronic address: a.raychaudhuri@erasmusmc.nl.
  • Jonkers J; Division of Molecular Pathology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Oncode Institute, 1066CX Amsterdam, the Netherlands. Electronic address: j.jonkers@nki.nl.
Mol Cell ; 81(22): 4692-4708.e9, 2021 11 18.
Article em En | MEDLINE | ID: mdl-34555355
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / DNA de Cadeia Simples / Proteína BRCA1 / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / DNA Ligase Dependente de ATP / Proteína 1 de Ligação à Proteína Supressora de Tumor p53 / Proteína Homóloga a MRE11 / Proteínas de Ligação a Poli-ADP-Ribose Limite: Animals / Female / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / DNA de Cadeia Simples / Proteína BRCA1 / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / DNA Ligase Dependente de ATP / Proteína 1 de Ligação à Proteína Supressora de Tumor p53 / Proteína Homóloga a MRE11 / Proteínas de Ligação a Poli-ADP-Ribose Limite: Animals / Female / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda