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Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
Ericson, Mark D; Doering, Skye R; Larson, Courtney M; Freeman, Katie T; LaVoi, Travis M; Donow, Haley M; Santos, Radleigh G; Cho, Rachel H; Koerperich, Zoe M; Giulianotti, Marc A; Pinilla, Clemencia; Houghten, Richard A; Haskell-Luevano, Carrie.
Afiliação
  • Ericson MD; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Doering SR; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Larson CM; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Freeman KT; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • LaVoi TM; Florida International University, Port St. Lucie, Florida 34987, United States.
  • Donow HM; Florida International University, Port St. Lucie, Florida 34987, United States.
  • Santos RG; Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, Florida 33314, United States.
  • Cho RH; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Koerperich ZM; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Giulianotti MA; Florida International University, Port St. Lucie, Florida 34987, United States.
  • Pinilla C; Florida International University, Port St. Lucie, Florida 34987, United States.
  • Houghten RA; Florida International University, Port St. Lucie, Florida 34987, United States.
  • Haskell-Luevano C; Department of Medicinal Chemistry and Institute for Translation Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
J Med Chem ; 64(19): 14860-14875, 2021 10 14.
Article em En | MEDLINE | ID: mdl-34592820
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Fragmentos de Peptídeos / Receptor Tipo 4 de Melanocortina / Proteína Relacionada com Agouti Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Fragmentos de Peptídeos / Receptor Tipo 4 de Melanocortina / Proteína Relacionada com Agouti Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos