Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine.

Bachmann, Fabio; Meyer Zu Schwabedissen, Henriette E; Duthaler, Urs; Krähenbühl, Stephan

Bachmann, Fabio; Meyer Zu Schwabedissen, Henriette E; Duthaler, Urs; Krähenbühl, Stephan.

Afiliação

Bachmann F; Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland.
Meyer Zu Schwabedissen HE; Department of Clinical Research, University of Basel, Switzerland.
Duthaler U; Department of Biomedicine, University of Basel, Switzerland.
Krähenbühl S; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Switzerland.

Br J Clin Pharmacol ; 88(4): 1885-1896, 2022 02.

Article em En | MEDLINE | ID: mdl-34648192

Assuntos

Citocromo P-450 CYP1A2; Dipirona; Ciprofloxacina; Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP2C19; Sistema Enzimático do Citocromo P-450/metabolismo; Dipirona/análogos & derivados; Dipirona/metabolismo; Fluconazol/farmacologia; Humanos; Masculino

Palavras-chave

4-formylaminoantipyrine; 4-methylaminantipyrine; CYP1A2; CYP2C19; metamizole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipirona / Citocromo P-450 CYP1A2 Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suíça

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