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Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion.
Wang, Qiang; Zhang, Lin; Zhang, Guo-Wei; Mao, Jian-Hua; Xi, Xiao-Dong; Jiang, Lu; Lv, Gang; Lu, Jing; Shen, Yan; Chen, Zhu; Zhu, Jiang; Chen, Sai-Juan.
Afiliação
  • Wang Q; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Zhang L; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Zhang GW; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Mao JH; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Xi XD; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Jiang L; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Lv G; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Lu J; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Shen Y; Research Center for Experimental Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
  • Chen Z; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; zchen@stn.sh.cn zhujiang@shsmu.edu.cn sjchen@stn.sh.cn.
  • Zhu J; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; zchen@stn.sh.cn zhujiang@shsmu.edu.cn sjchen@stn.sh.cn.
  • Chen SJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; zchen@stn.sh.cn zhujiang@shsmu.edu.cn sjchen@stn.sh.cn.
Proc Natl Acad Sci U S A ; 118(42)2021 10 19.
Article em En | MEDLINE | ID: mdl-34649996
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator IX / Dependovirus / Hepatócitos / Alelos / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator IX / Dependovirus / Hepatócitos / Alelos / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China