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The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling.
Hyun, Sang W; Imamura, Akihiro; Ishida, Hideharu; Piepenbrink, Kurt H; Goldblum, Simeon E; Lillehoj, Erik P.
Afiliação
  • Hyun SW; US Department of Veterans Affairs, Veterans Affairs Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Imamura A; Department of Applied Bio-organic Chemistry, Gifu University, Gifu, Japan.
  • Ishida H; Department of Applied Bio-organic Chemistry, Gifu University, Gifu, Japan.
  • Piepenbrink KH; Food Science and Technology Department, University of Nebraska, Lincoln, Nebraska, USA.
  • Goldblum SE; US Department of Veterans Affairs, Veterans Affairs Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Lillehoj EP; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address: elillehoj@som.umaryland.edu.
J Biol Chem ; 297(5): 101337, 2021 11.
Article em En | MEDLINE | ID: mdl-34688655
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Mucina-1 / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Neuraminidase Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Mucina-1 / Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt / Neuraminidase Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos