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DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity.
Roy, Roshni; Ramamoorthy, Senthilkumar; Shapiro, Benjamin D; Kaileh, Mary; Hernandez, Dena; Sarantopoulou, Dimitra; Arepalli, Sampath; Boller, Sören; Singh, Amit; Bektas, Arsun; Kim, Jaekwan; Moore, Ann Zenobia; Tanaka, Toshiko; McKelvey, Julia; Zukley, Linda; Nguyen, Cuong; Wallace, Tonya; Dunn, Christopher; Wersto, Robert; Wood, William; Piao, Yulan; Becker, Kevin G; Coletta, Christopher; De, Supriyo; Sen, Jyoti Misra; Battle, Alexis; Weng, Nan-Ping; Grosschedl, Rudolf; Ferrucci, Luigi; Sen, Ranjan.
Afiliação
  • Roy R; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Ramamoorthy S; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
  • Shapiro BD; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
  • Kaileh M; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Hernandez D; Laboratory of Neurogenetics, National Institute on Aging, Baltimore, MD, USA.
  • Sarantopoulou D; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Arepalli S; Laboratory of Neurogenetics, National Institute on Aging, Baltimore, MD, USA.
  • Boller S; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
  • Singh A; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Bektas A; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
  • Kim J; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Moore AZ; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
  • Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
  • McKelvey J; Clinical Research Core, National Institute on Aging, Baltimore, MD, USA.
  • Zukley L; Clinical Research Core, National Institute on Aging, Baltimore, MD, USA.
  • Nguyen C; Flow Cytometry Unit, National Institute on Aging, Baltimore, MD, USA.
  • Wallace T; Flow Cytometry Unit, National Institute on Aging, Baltimore, MD, USA.
  • Dunn C; Flow Cytometry Unit, National Institute on Aging, Baltimore, MD, USA.
  • Wersto R; Flow Cytometry Unit, National Institute on Aging, Baltimore, MD, USA.
  • Wood W; Laboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.
  • Piao Y; Laboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.
  • Becker KG; Laboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.
  • Coletta C; Laboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.
  • De S; Laboratory of Genetics & Genomics, National Institute on Aging, Baltimore, MD, USA.
  • Sen JM; Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA.
  • Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
  • Weng NP; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
  • Grosschedl R; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
  • Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
  • Sen R; Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA. Electronic address: senranja@grc.nia.nih.gov.
Immunity ; 54(11): 2465-2480.e5, 2021 11 09.
Article em En | MEDLINE | ID: mdl-34706222
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica / Metilação de DNA / Epigênese Genética / Epigenômica / Transcriptoma / Imunidade Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica / Metilação de DNA / Epigênese Genética / Epigenômica / Transcriptoma / Imunidade Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos