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Superoxide dismutase as multipotent therapeutic antioxidant enzyme: Role in human diseases.
Saxena, Priyanka; Selvaraj, Kanagarethinam; Khare, Sunil Kumar; Chaudhary, Nidhee.
Afiliação
  • Saxena P; Centre for Biotechnology and Biochemical Engineering, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, 201313, India.
  • Selvaraj K; Centre for Biotechnology and Biochemical Engineering, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, 201313, India.
  • Khare SK; R&D & Institute Chair Professor of Biochemistry, Enzyme and Microbial Biochemistry Lab, Department of Chemistry, Indian Institute of Technology Delhi, New Delhi, 110016, India.
  • Chaudhary N; Centre for Biotechnology and Biochemical Engineering, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, 201313, India. nchaudhary@amity.edu.
Biotechnol Lett ; 44(1): 1-22, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34734354
Reactive oxygen species (ROS) is consistently recognized as a threat to living organisms, especially for human beings. For proper working of cellular signaling, functioning, and survival, a strict and balanced level of ROS is necessary. Superoxide dismutase (SOD); a group of metalloenzymes provides an important antioxidant defense mechanism, required to preserve the level of ROS in the body. The enzyme reveals the therapeutic potential against various diseases due to a deficiency in the ROS level. The review illustrates the numerous clinical aspects of SOD in various physiological and pathological conditions such as cancer, diabetes, arthritis, cardiovascular, neurodegenerative diseases, etc., with the mechanism of action. Despite limitations, the SOD enzyme has proved as a powerful tool against diseases, and various forms of conjugates and mimetics have been developed and reported to make it more efficient. Extensive studies need in this direction for use of natural SOD-based therapeutics for the prevention and cure of diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Neoplasias Limite: Humans Idioma: En Revista: Biotechnol Lett Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Neoplasias Limite: Humans Idioma: En Revista: Biotechnol Lett Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia