TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.

Willemsen, Joschka; Neuhoff, Marie-Therese; Hoyler, Thomas; Noir, Emma; Tessier, Clemence; Sarret, Sophie; Thorsen, Tara N; Littlewood-Evans, Amanda; Zhang, Juan; Hasan, Maroof; Rush, James S; Guerini, Danilo; Siegel, Richard M

Willemsen, Joschka; Neuhoff, Marie-Therese; Hoyler, Thomas; Noir, Emma; Tessier, Clemence; Sarret, Sophie; Thorsen, Tara N; Littlewood-Evans, Amanda; Zhang, Juan; Hasan, Maroof; Rush, James S; Guerini, Danilo; Siegel, Richard M.

Afiliação

Willemsen J; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland. Electronic address: joschka.willemsen@novartis.com.
Neuhoff MT; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Hoyler T; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Noir E; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Tessier C; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Sarret S; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Thorsen TN; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Littlewood-Evans A; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Zhang J; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Hasan M; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Rush JS; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Guerini D; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.
Siegel RM; Novartis Institutes for BioMedical Research, Novartis Campus, Basel 4002, Switzerland.

Cell Rep ; 37(6): 109977, 2021 11 09.

Article em En | MEDLINE | ID: mdl-34758308

Assuntos

Artrite Experimental/imunologia; DNA Mitocondrial/metabolismo; Imunidade Inata; Inflamação/imunologia; Interferon Tipo I/farmacologia; Proteínas de Membrana/metabolismo; Nucleotidiltransferases/fisiologia; Fator de Necrose Tumoral alfa/farmacologia; Animais; Artrite Experimental/tratamento farmacológico; Artrite Experimental/genética; Artrite Experimental/metabolismo; DNA Mitocondrial/efeitos dos fármacos; Feminino; Inflamação/tratamento farmacológico; Inflamação/genética; Inflamação/metabolismo; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Macrófagos/imunologia; Masculino; Proteínas de Membrana/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitofagia

Palavras-chave

ISG; STING; TNF; arthritis; autoimmune; cGAS; interferon; mitophagy; mtDNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / DNA Mitocondrial / Interferon Tipo I / Fator de Necrose Tumoral alfa / Imunidade Inata / Inflamação / Proteínas de Membrana / Nucleotidiltransferases Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2021 Tipo de documento: Article

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