Increased frequencies of alpha-naphthoflavone induced sister chromatid exchanges in long-term survivors of childhood acute lymphoblastic leukemia.
Cancer Lett
; 36(2): 213-9, 1987 Aug.
Article
em En
| MEDLINE
| ID: mdl-3476194
ABSTRACT
Cultures of whole-blood were established from 12 children (mean age = 13.5 years) surviving acute lymphoblastic leukemia (mean time of discontinued therapy = 4.5 years) and 10 age-matched controls were assessed for the level of baseline, alpha-naphthoflavone (ANF) and methyl-methane-sulphonate (MMS) induced sister chromatid exchanges (SCEs). The average baseline levels of SCEs in the patient group (7.65) and in the control (6.72) were different at a statistical marginal level (P = 0.05). No statistical difference was observed in the levels of MMS-induced SCEs between the two groups (P greater than 0.1). In contrast, highly significant differences (P = 0.003) were observed in the level of ANF-induced SCE-levels between the patients (10.78) and the controls (8.76).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Troca de Cromátide Irmã
/
Benzoflavonas
/
Flavonoides
/
Leucemia Linfoide
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1987
Tipo de documento:
Article