Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

Madsen, Ralitsa R; Erickson, Emily C; Rueda, Oscar M; Robin, Xavier; Caldas, Carlos; Toker, Alex; Semple, Robert K; Vanhaesebroeck, Bart

Madsen, Ralitsa R; Erickson, Emily C; Rueda, Oscar M; Robin, Xavier; Caldas, Carlos; Toker, Alex; Semple, Robert K; Vanhaesebroeck, Bart.

Afiliação

Madsen RR; University College London Cancer Institute, Paul O'Gorman Building, University College London, London, United Kingdom.
Erickson EC; Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Rueda OM; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.
Robin X; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Caldas C; NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Toker A; SIB Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Basel, Switzerland.
Semple RK; Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.
Vanhaesebroeck B; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.

PLoS Genet ; 17(11): e1009876, 2021 11.

Article em En | MEDLINE | ID: mdl-34762647

Assuntos

Neoplasias da Mama/patologia; Classe I de Fosfatidilinositol 3-Quinases/metabolismo; Células-Tronco Neoplásicas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Transcriptoma; Neoplasias da Mama/metabolismo; Feminino; Genótipo; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Mama / Transdução de Sinais / Proteínas Proto-Oncogênicas c-akt / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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