Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system.

Su, Xiaomin; Cao, Yongbin; Liu, Yao; Ouyang, Boshu; Ning, Bo; Wang, Yang; Guo, Huishu; Pang, Zhiqing; Shen, Shun

Su, Xiaomin; Cao, Yongbin; Liu, Yao; Ouyang, Boshu; Ning, Bo; Wang, Yang; Guo, Huishu; Pang, Zhiqing; Shen, Shun.

Afiliação

Su X; Central Laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
Cao Y; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.
Liu Y; Zhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, 519000, Guangdong, PR China.
Ouyang B; The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Ning B; Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Wang Y; Institutes of Integrative Medicine, Fudan University, Shanghai, China.
Guo H; Central Laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
Pang Z; Central Laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
Shen S; Central Laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.

Mater Today Bio ; 12: 100154, 2021 Sep.

Article em En | MEDLINE | ID: mdl-34778741

Palavras-chave

ABTS, 2,2-Azobis (3-ethylbenzothiazoline-6-sulfonic acid); AIPH, 2,2'-azobis [2-(2-imidazolin-2-yl) propane] dihydrochloride; ALG, sodium alginate; Alkyl radicals; CCK8, Cell counting kit-8; CLSM, confocal laser scanning microscope; DAPI, 4',6-diamidino-2-phenylindole; DCFH-DA, 2,7-dichlorofluorescin diacetate; DFO, deferoxamine mesylate; DLS, dynamic light scattering; DMEM, Dulbecco's Modified Eagle's Medium; DTNB, 5,5'-Dithiobis-(2-nitrobenzoic acid); FBS, fetal bovine serum; Fer-1, Ferrostatin -1; Ferroptosis; GA, gambogic acid; GPX4, glutathione peroxidase 4; GSH, glutathione; Glutathione peroxidase; HE, hematoxylin eosin; HSP90, heat shock protein 90; Hydrogel; IR, inhibitory rate; LPO, lipid peroxides; NPs, nanodrugs; PTT, photothermal therapy; ROS, reactive oxygen species; Redox homeostasis; Râ¢, alkyl radicals

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mater Today Bio Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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