[Effect of dietary water-soluble vitamins on the poor prognosis of low-grade cervical intraepithelial neoplasia-a prospective cohort study].
Zhonghua Liu Xing Bing Xue Za Zhi
; 42(6): 1097-1102, 2021 Jun 10.
Article
em Zh
| MEDLINE
| ID: mdl-34814514
ABSTRACT
Objective:
To explore the effect of dietary water-soluble vitamins on the poor prognosis of low-grade cervical intraepithelial neoplasia (CINâ ).Methods:
A total of 564 participants with CINâ were selected from a community-based married women cohort established in 2014. The general baseline information was collected, and HPV genotyping was detected. A food frequency questionnaire was used to investigate dietary water-soluble vitamins' consumption and determine their exposure levels. The follow-up program was carried out for 12 months, and the regression, persistence, and progression of CINâ was determined according to histopathological results at 12-month.Results:
The low-levels of dietary water-soluble vitamins could promote CINâ 's persistence and progression, showing the increasing tendency of CINâ poor prognosis with the decrease of water-soluble vitamin levels. Especially folate, VB1, VB2, VB6, niacin, biotin, and VC (RR values were 15.22, 1.86, 1.92, 2.11, 2.98, 2.14, 2.19, respectively) played an important role. Considering the status of high-risk human papillomavirus (HR-HPV) infection, our results showed that the low levels of folate, niacin, biotin could promote the poor prognosis of CINâ .Conclusions:
The low-level of dietary water-soluble vitamins could facilitate the poor prognosis of CINâ . In addition, folate, niacin, biotin were more effective on HR-HPV positive women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
/
Infecções por Papillomavirus
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
Zh
Revista:
Zhonghua Liu Xing Bing Xue Za Zhi
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China